Decline in body weight in the Alzheimer's disease continuum Lead Investigator: Amanda Jimenez Institution : Hospital Clinic de Barcelona E-Mail : ajimene1@clinic.ub.es Proposal ID : 737 Proposal Description: Pre-clinical and prodromal Alzheimer???s Disease have been both associated with weight loss. Recently published data suggested that weight loss might be even present decades before of mild cognitive decline diagnosis. However, precise weight trajectories across AD stages have not yet been evaluated and relation between weight loss and risk of clinical progression have not clearly defined. Furthermore, mechanisms involved in AD related weight loss have not yet been identified. GOALS: 1) To evaluate weight trajectories across Alzheimer???s disease stages. 2) To compare clinical and neuropsychological characteristics, brain structure at baseline and clinical progression between subjects with or without significant weight loss throughout follow-up at each AD stage. EXPECTED RESULTS: Pre-clinical AD will be associated with future weight loss. Weight loss will continue during prodromal and clinical AD stages. Subjects with weight loss will present faster clinical progression and will show higher neuropsychiatric symptoms and higher atrophy in brain areas involved in appetite control. Better understanding of significance of weight loss trough AD continuum and the factors involved in body weight decline might be useful to identify subjects at risk of dementia and to prevent significant weight loss and clinical deterioration. Specific objectives: 1) Tested the hypothesis of weight loss as early non-cognitive marker of pre-clinical and prodromal AD 2) Tested the hypothesis of reve